Effect of Acetylsalicylic Acid (Aspirin ) and Dexamethasone on Vernal Conjunctivitis – A Comparative Analysis

Akpalaba, R.U.E And Ilade, A.


Vernal conjunctivitis is a common external eye disease, particularly amongst children and young adults, characterized by severe itching, papillae formation and brownish colouration of the eyes among others. Various treatment modalities are available with their various side effects. A six-week open study was carried out to evaluate the effect of Aspirin and Dexamethasone in the treatment of vernal conjunctivitis. Twenty four patients with a mean age of 12.42 5.77 years were included in the study. The patients were divided into four groups A, B, C, D. Group A had a combined therapy of Aspirin and Dexamethasone (Maxidex 0.1% of eye drop); Group B had Aspirin therapy with Placebo drops(Normalsaline); GroupChad Dexamethasone therapy alone, while Group D had Placebo, drops only. A marked improvement of the clinical features of vernal conjunctivitis, namely itching, limbal or tarsal papillae, conjunctival or scleral discolouration was noted within 6 weeks in group A, B and C while the control group, D showed no improvement. Thus Aspirin and Dexamethasone reduced significantly the clinical features of vernal conjunctivitis. Using the t-test at p<0.05, p<0.01 and p<0.001, a comparative analysis was done and no significant difference in efficacy was found in groups A, B and C. Therefore, Aspirin and Dexamethasone are comparable in action in the therapeutic management of vernal conjunctivitis and aspirin can be used as the only treatment option in patients that can tolerate its use.

Keywords: Aspirin, vernal conjunctivitis, dexamethasone, itching, papillae, conjunctival discolouration.

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