Comparative Efficacy Of Topical Ciprofloxacin On Staphylococcus Aureus and Pseudomonas Aureginosa in vitro

Ikonne, E. U. and Odozor, O.


Ciprofloxacin is often considered a drug of the first choice in the treatment of bacterial keratitis. Most of the ocular infections are caused by Staphylococcus aureus and Pseudomonas aeruginosa. This study set to compare the efficacy of ciprofloxacin on these two microorganisms in vitro. The “agar well diffusion” and the 10-fold serial dilution techniques were used respectively for the tests. Results of the sensitivity test showed that P.aeruginosa had a higher mean zone of inhibition (4.72cm) than S. aureus(3.73cm), showing that ciprofloxacin is more efficacious against P. aeruginosa than against S.aureus. Ciprofloxacin is therefore recommended as a drug of first choice in the treatment of ocular infection from Pseudomonas aeruginosa.

Keywords: Ciprofloxacin,Pseudomonas aeruginosa, Staphylococcus aureus, bacterial keratitis

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